Publications
Find new discoveries in pharmacogenomics through learning from our internal research.
Targeted adaptive sampling enables clinical pharmacogenomics testing and genome-wide genotyping
PublicationsPharmacogenomics (PGx) testing improves medication safety and efficacy by identifying genetic variants that affect drug response. However, current technologies often fail to resolve complex loci, detect structural variants, or phase alleles accurately.
Read MoreCYP2D6 Genotyping for Optimization of Tamoxifen Therapy in Indonesian Women with ER+ Breast Cancer
PublicationsCertain CYP2D6 genotypes are linked to a lower efficacy of tamoxifen therapy. This study aimed to observe CYP2D6 polymorphisms and examine the impact of CYP2D6 genotyping among tamoxifen-treated breast cancer patients in Indonesia.
Read MoreImplementation of Pre-emptive Pharmacogenomics Testing in Outpatient Clinics in Asia (IMPT study)
PublicationsIn view of the limited data related to preemptive pharmacogenomics (PGx) testing in the primary care setting, we designed a study to assess the feasibility of implementing preemptive PGx services at outpatient clinics...
Read MoreWhat do women want to see in a personalized breast cancer risk report? A qualitative study of Asian women of two countries
PublicationsA breast cancer risk assessment tool using Polygenic Risk Score (PRS) assessment of 313 single nucleotide polymorphisms and a risk prediction algorithm from the Gail Model had been established and validated for Asian population.
Read MoreDevelopment and validation of a pharmacogenomics reporting workflow based on the Illumina global screening array chip
PublicationsMicroarrays are a well-established and widely adopted technology capable of interrogating hundreds of thousands of loci across the human genome. Combined with imputation to cover common variants not included in the chip design, they offer a cost-effective solution for large-scale genetic studies.
Read MoreThe variation landscape of CYP2D6 in a multi-ethnic Asian population
PublicationsCytochrome P450 2D6 (CYP2D6) plays a crucial role in metabolizing approximately 20% of medications prescribed clinically.
Read MoreDevelopment and validation of a pharmacogenomics reporting workflow based on the Illumina Global Screening Array chip
PublicationsMicroarrays are a well-established and widely adopted technology capable of interrogating hundreds of thousands of loci across the human genome. Combined with imputation to cover common variants not included in the chip design, they offer a cost-effective solution for large-scale genetic studies.
Read MoreA combined risk model shows viability for personalized breast cancer risk assessment in the Indonesian population
PublicationsBreast cancer remains a significant concern worldwide, with a rising incidence in Indonesia. This study aims to evaluate the applicability of risk-based screening approaches in the Indonesian demographic through a case-control study involving 305 women.
Read MoreThe Impacts of Nutrigenetic Testing and Counseling Towards Eating Behaviors of The Indonesian Population
PublicationsNutrigenetics testing is increasingly popular due to its perceived benefits. However currently, the impacts of nutrigenetics towards attitudes and healthy eating behavior remains elusive, particularly among the Indonesian population.
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